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1.
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell
; 186(24): 5347-5362.e24, 2023 11 22.
Article
in English
| MEDLINE | ID: mdl-37963465
2.
Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.
J Med Virol
; 96(3): e29502, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38450817
3.
Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses.
J Med Virol
; 95(7): e28968, 2023 07.
Article
in English
| MEDLINE | ID: mdl-37489704
4.
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.
Bioorg Med Chem
; 96: 117535, 2023 12 15.
Article
in English
| MEDLINE | ID: mdl-37956505
5.
In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.
Bioorg Med Chem
; 96: 117484, 2023 12 15.
Article
in English
| MEDLINE | ID: mdl-37976805
6.
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.
Bioorg Chem
; 134: 106465, 2023 05.
Article
in English
| MEDLINE | ID: mdl-36933339
7.
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Int J Mol Sci
; 24(2)2023 Jan 07.
Article
in English
| MEDLINE | ID: mdl-36674730
8.
In Silico Discovery of Small-Molecule Inhibitors Targeting SARS-CoV-2 Main Protease.
Molecules
; 28(14)2023 Jul 10.
Article
in English
| MEDLINE | ID: mdl-37513194
9.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Article
in English
| MEDLINE | ID: mdl-35949003
10.
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem
; 53: 116531, 2022 01 01.
Article
in English
| MEDLINE | ID: mdl-34890994
11.
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.
Chem Soc Rev
; 50(7): 4514-4540, 2021 Apr 07.
Article
in English
| MEDLINE | ID: mdl-33595031
12.
Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary.
Molecules
; 27(3)2022 Jan 27.
Article
in English
| MEDLINE | ID: mdl-35164129
13.
Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.
Molecules
; 27(21)2022 Nov 03.
Article
in English
| MEDLINE | ID: mdl-36364360
14.
Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778.
Molecules
; 27(18)2022 Sep 14.
Article
in English
| MEDLINE | ID: mdl-36144715
15.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules
; 27(18)2022 Sep 14.
Article
in English
| MEDLINE | ID: mdl-36144727
16.
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Molecules
; 28(1)2022 Dec 25.
Article
in English
| MEDLINE | ID: mdl-36615354
17.
Tumor-Selective Activation of Toll-Like Receptor 7/8 Agonist Nano-Immunomodulator Generates Safe Anti-Tumor Immune Responses upon Systemic Administration.
Angew Chem Int Ed Engl
; 61(52): e202214992, 2022 12 23.
Article
in English
| MEDLINE | ID: mdl-36331428
18.
Punicalagin is a neuraminidase inhibitor of influenza viruses.
J Med Virol
; 93(6): 3465-3472, 2021 06.
Article
in English
| MEDLINE | ID: mdl-32827314
19.
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
Bioorg Med Chem
; 42: 116239, 2021 07 15.
Article
in English
| MEDLINE | ID: mdl-34090079
20.
Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.
Bioorg Med Chem
; 48: 116414, 2021 10 15.
Article
in English
| MEDLINE | ID: mdl-34562701